Trial Purpose

This study will collect bone marrow (BM) aspirate samples from patients with relapsed refractory multiple myeloma (RRMM) prior to the start of a new treatment regimen for the purposes of prospectively measuring mass accumulation rate (MAR) as a biomarker of patient response to that regimen.

The primary study objective is to explore whether the MAR biomarker can predict patient response in RRMM patients. In order to enable this primary objective, two patient groups will be required. First, a small number of patients with recently diagnosed with multiple myeloma and never treated (Vanguard cohort) will be enrolled to help define drug concentrations used for testing. A second larger group of patients with RRMM will then be enrolled and serve as the primary study cohort. Data will be collected to estimate the biomarker’s predictive properties and to support improvement of the MAR biomarker through additional research and discovery based on the data collected during the study.

Trial Summary